An acid gets its characteristics from the hydrogen atoms of its molecules. Strong acids have weakly bound hydrogen atoms, and the molecules easily separate from them in solution. How many of these hydrogen atoms dissociate and form hydrogen ions determines the strength of an acid. Strong acids lose most or all of their hydrogen atoms in a water solution and form H₃O ions with a positive charge. The rest of the acid molecule forms a separate ion with a negative charge.

The strongest commonly available acids include hydrochloric acid, HCl, and sulfuric acid, H₂SO₄. The bond between the hydrogen and chlorine atoms of hydrochloric acid is weak enough that all the hydrogen atoms dissociate themselves from the chlorine atoms when the acid dissolves in water. The hydrogen atoms in the hydrochloric acid molecules lost their single electrons to the chlorine atoms in the chemical reaction that formed the hydrochloric acid compound. As a result, the hydrogen atoms form ions with a plus one charge, and the chlorine atoms form ions with a charge of minus one.

Similarly, the hydrogen atoms of the sulfuric acid molecule lost their electrons in the chemical reaction that formed sulfuric acid. They are also weakly held and dissociate themselves from the SO₄ atoms to form two hydrogen ions with a plus one charge. The SO₄ atoms form a negative sulfate ion with a charge of minus two.

Where the hydrogen ions of strong acids dissociate in water and give the solution the characteristics of an acid, the hydroxide ion plays the same role for strong bases. Sodium hydroxide, NaOH, and calcium hydroxide, Ca(OH)₂, are examples of strong bases that dissociate completely in water. The weakly held OH ion with a charge of minus one dissociates from the sodium ion with a charge of plus one or the calcium ion with a charge of plus two. The large number of OH ions in the water gives the solution the characteristics of a strong base.

Because strong acids and bases completely dissociate in water, they can neutralize each other and produce a stable salt. If the correct proportions of an acid and a base are slowly mixed, the H hydrogen ions with a positive charge combine with the negatively charged OH hydroxide ions to form water. The other parts of the molecules dissolved in the water combine to form a salt.

For example, if sodium hydroxide is slowly added to hydrochloric acid, the OH ions of the sodium hydroxide combine with the H ions of the hydrochloric acid to form water. The sodium ions combine with the chlorine ions to form sodium chloride or table salt. Because of the strength of the acid and the base, all their ions dissolved, and all combined to form water. Strong acids and strong bases can completely neutralize each other.